BDBM154576 K03861 (1)
SMILES CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
InChI Key InChIKey=PWDLXPJQFNVTNL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 154576
Affinity DataIC50: 7.20E+3nMpH: 7.5Assay Description:For IC50 measurements, a 384-well microtiter plate contained 8-point serial dilutions of inhibitors and 16-point serial dilutions of staurosporine as...More data for this Ligand-Target Pair
Affinity DataKd: 18.6nMpH: 7.5 T: 2°CAssay Description:All ITC experiments were performed using a VP-ITC (Microcal, Northampton, MA) instrument at 10 or 15 °C in 50 mM HEPES, pH 7.5, 300 mM NaCl, and 1 mM...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 154576
CellCyclin-dependent protein kinase 2 variant (CDK2 C118L)(Homo sapiens (Human))
University of Oxford
University of Oxford
ITC DataΔG°: -10.2kcal/mole −TΔS°: 4.75kcal/mole ΔH°: -14.9kcal/mole logk: 5.51E+7
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C